The Amalgamation is the final boss of Operation: V.I.D.E.O.G.A.M.E. It is a giant monster created by combining Gramma Stuffum, Common Cold, Count Spankulot, Stickybeard, Knightbrace and Toiletnator using the "Amalgamator." It is sent to destroy the KND Moonbase and is fought using a giant robot created from the components of the Moonbase called the T.R.E.E.H.E.M.O.T.H. and was split into their original forms due to its fusion form.
Since the Amalgamation is a merged form of the six villains that were used for its combination, it has various parts of the villains. It has Gramma Stuffum's head, body, upper arms, left leg and upper half of right leg, Common Cold's right arm and snot-cannon, Count Spankulot's fangs and gloves behind its back, Stickybeard's beard, skull symbol, and candy peg leg, Knightbrace's left arm, headgear, and belt, and Toiletnator's lid and toilet paper cape.
- The Fusion form of the KND villain parodies SpaceGodzilla from Godzilla franchise, Mega-Mix from Crash Bandicoot: The Huge Adventure and Spectral Empress Iliess' Chimera Form called Evil Empress Iliess from Seijuu Sentai Gingaman.
- The Toiletnator was originally not meant to be part of the Amalgamation, as Father was surprised that he was with the other villains, claiming "He'll ruin everything!"