|Occupation||Assistant to President Jimmy|
|Voice|| Grey DeLisle (Operation: P.R.E.S.I.D.E.N.T.)|
Anndi McAfee (Operation: S.N.O.W.I.N.G.)
Anna Worthington was the secretary to 4th Grade President James "Jimmy" Nixon McGarfield. She is also the niece of the Common Cold, and occasionally asks him for special favors. She was first seen working with the Delightful Children From Down The Lane in an effort to intercept School Bus One at any cost, but she was not allowed to board the bus, which ended her part in this plan.
In Operation: S.N.O.W.I.N.G., she is now working with Jimmy instead of against him (likely because he turned evil), and was jealous of Jimmy's love for Lizzie, because she loves him. So in revenge she helped the KND by freeing Numbuhs 2, 3 , 4 and 5 from their shackles, allowing them to keep the Hall Squad busy so Numbuh 1 could deal with Jimmy. Despite helping the KND she was still arrested, and finally declares her love for Jimmy as the Numbuh 44 twins are escorting them onto the S.P.R.A.Y.S.H.I.P., hopeful that he will learn to love her back while they are imprisoned.