The Common Cold is an eternally ill villain who wishes to spread his cold to everyone else in the world. He uses a machine to fire mucus from his nose at his enemies. He can routinely be defeated with orange juice. The Common Cold first appears in Operation: T.O.M.M.Y., in which Numbuh Two's brother, Tommy, aids the Common Cold out of jealousy for the KND, building a machine for him that transforms him into the "Flu Bug". Numbuh Two's mother used chicken soup to counter the machine and defeat the villain. The Common Cold never got a starring role in an episode again, but made several minor appearances. He is the boss of Operation: S.N.O.T.B.O.M.B.E.R in Operation: V.I.D.E.O.G.A.M.E.. In Operation: S.N.O.W.I.N.G., it is revealed that he is the uncle of Anna Worthington, and was responsible for making Numbuh 1 sick to keep him from interfering with Jimmy's plans.
The Common Cold's weaknesses include chicken soup and Vitamin C. However, Vitamin C does not treat or cure the Common Cold.
The Common Cold's jetpack resembles a green propane tank.
His voice actor, Tom Kenny, also voices a character from the game "Escape From Monkey Island" called Deadeye Dave who had a cold and as a result, the two sound very familiar.