Only one KND operative per planet may be chosen to join the ranks of the Galactic KND, a decision which is made through an elaborate and highly secretive process.
During the final season of Codename: Kids Next Door, Numbuh 1 is chosen to be Earth's Galactic KND operative. At the end of Operation: I.N.T.E.R.V.I.E.W.S., he passes his final test and confronts Numbuh 74.239, upon which the existence of the Galactic KND is revealed to him and the viewer. But in the end of the movie, it is seen that Numbuh 1 returns to Earth.
Sequel or Spin Off
In the new series trailer, it's implied that the Galactic KND are actually much more sinister than previously believed, being willing to actually destroy adults and planets that they deem as "infested" with adults.
This coincides with their cover- Splinter Cell - who was believed to want to eradicate the world of all adults instead of just the evil ones.
It also expands on their claims in Operation: I.N.T.E.R.V.I.E.W.S. that adulthood is a disease.
It is hinted, the Galactic KND are the main antagonists of the sequel series, because of they plan to rid the universe of all adults.
It is also presumed that Numbuh 1 has been either corrupted or manipulated by the Galactic KND to become their pawn or loyal servant.
UPDATE: It is to be noted that on the Rainbow Monkey Website, there is an eye missing on the Rainbow Monkey's face where there were two eyes previously. The left eye now goes missing twice. Whether or not this means anything is uncertain.