Mrs. Uno
Mrs. Uno
Occupation Housekeeper & Former Kids Next Door Operative
Voice Jennifer Hale
Cameos N/A

Numbuh 1's mother, Mrs. Uno is a jolly British-American lady. Her voice was first heard in Operation: C.A.N.N.O.N., calling Numbuh 1 to start their trip to Hap-Happy Land. She was physically seen for the first time, although only from the waist down, in Operation: K.N.O.T. where she is seen doing a crossword puzzle while her son wrestles with a necktie. In the series finale, Operation: I.N.T.E.R.V.I.E.W.S., it is revealed that she was once Numbuh 999, the first female operative in the modern Kids Next Door Organization.